1 Effects of three antihistamines, triprolidine (10 mg) in a sustained release form, astemizole (10 mg) and terfenadine (60 mg), have been studied on dynamic visual acuity and on the response of the pupil to light, together with critical flicker fusion, digit symbol substitution and cancellation, and subjective assessment of mood. The study was double-blind and effects were observed from 0.5-4.0 h after ingestion. 2 Triprolidine impaired dynamic acuity and reduced the threshold for subjective fusion of a flickering light, but there were no changes with astemizole or terfenadine. The diameter of the pupil and its response to light were not changed by the drugs. 3 Performance on digit symbol substitution and cancellation was not altered by the drugs. 4 Astemizole and terfenadine are promising antihistamines for those involved in skilled activity.
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